Sustained Interleukin-10 Transgene Expression Following Intra-Articular AAV5-IL-10 Administration to Horses
نویسندگان
چکیده
منابع مشابه
MODULATION OF INTERLEUKIN-1Β (IL-1Β ), TUMOR NECROSIS FACTOR–Α (TNF-Α) AND INTERLEUKIN-10 (IL-10 ) GENES EXPRESSION FOLLOWING CONCURRENT TRAINING IN WOMEN WITH TYPE2 DIABETES
Background: The purpose of this study was to investigate the effect of concurrent training on pre-inflammatory (IL-1β, TNF-α) and anti-inflammatory (IL-10) cytokines gene expression in women with type2 diabetes. Methods: 18-patients (age30-38, >130 glycemic index) were selected, randomly, and divided into control (n=6) the concurrent training(diabetes, n=6) and the concurrent training (healthy...
متن کاملAssessment of Analgesic Efficacy of Intra-articular Tramadol Administration Following Arthroscopic Surgery in Horses - A Pilot Study
Objective-The aim of this study was to evaluate the analgesic efficacy of intra-articular administration of tramadol in horses following arthroscopic surgery. Design-Experimental study. Animals-Ten Warmblood horses Procedures- Horses underwent arthroscopic surgery of the tarsocrural joint (TCJ) (8 horses) and ...
متن کاملThe frequency of interleukin-10 (IL-10) polymorphisms in patients with peptic ulcer and chronic gastritis
ABSTRACT Introduction: Peptic ulcer is a common problem in medicine with serious impacts on the quality of life of patients. It has been shown that Helicobacter pylori infection is related with inflammatory responses of gastric mucosa. However, some patients remain asymptomatic. Sustained colonization and chronic inflammation increase the risk of gastritis and peptic ulcer. The a...
متن کاملInterleukin-10 (IL-10) in experimental visceral leishmaniasis and IL-10 receptor blockade as immunotherapy.
Interleukin-10 (IL-10) is thought to promote intracellular infection, including human visceral leishmaniasis, by disabling Th1 cell-type responses and/or deactivating parasitized tissue macrophages. To develop a rationale for IL-10 inhibition as treatment in visceral infection, Th1 cytokine-driven responses were characterized in Leishmania donovani-infected BALB/c mice in which IL-10 was absent...
متن کاملThe role of interleukin-10 (IL-10) in IL-15-mediated T-cell responses.
Interleukin-15 (IL-15) is a potent T-cell stimulating factor, which has recently been used for pre-clinical in vivo immunotherapy. Here, the IL-15 effect on CD3-stimulated peripheral human T cells was investigated. IL-15 induced a significant T-cell proliferation and upregulated CD25 expression. IL-15 significantly enhanced T-cell production of interferon-gamma (IFN-gamma), tumor necrosis facto...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Human Gene Therapy
سال: 2020
ISSN: 1043-0342,1557-7422
DOI: 10.1089/hum.2019.195